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also inhibits AChE with IC50 of 6
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It shows 4- and 11-fold greater selectivity against Plk2 and Plk3
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9 nM in cell-free assays for APPL and Notch cleavage
GW788388 75cm also inhibits AChE with IC50GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell free assay, also inhibits TGF ? type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
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