Our brain simply remembers how a card should look like (or anything else)
Finding protection for Box Topper cards requires specific oversized sleeves around 3.5 x 5
If Infesting Radroach is milled at the same time an opponent mills a nonland card (for example, because of the activated ability of Raul, Trouble Shooter), Infesting Radroach's ability will trigger
These cards established strategic mechanics that are still core to the Pokmon TCG today.
The variant breakdown (Extended Art, Showcase, basic-land arts, etc) lives in the Tracker/Odds tab if you want per-variant progress
However, these anti-synergies always sound worse in theory than they are in practice (see the current build of UR Murktide), particularly giving the turbo-fueling that DRC provides