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I have also included all of the cards that sprang to mind from the cube that fulfil the remit of being a game improving card in an honourable mentions section
Abrade is good enough without artifacts to target and an absolute life saver sometimes where there are
With a few counter doublers in play, you can easily pile buffs on Jenova, turning her into a Mutant-making machine
"Wilds Blue Yonder, Part 1"
Instead, he had to make due with a slightly less extreme set of threats, most of which were designed to be especially good at beating whatever the opponents best threat was (given the nature of Hypergenesis letting them play their best threat for free)