1 Crucible of the Spirit Dragon
Unlike standard Hyper Rares (which are gold versions of existing illustrations), MHRs feature a unique original artwork
In the manga, Joey is frustrated about him throwing the Duel, so Mako begins explaining the significance of this card for him and the relationship with his father with this quote
Whereas Jigglypuff appears to be very cute and friendly, Scream Tail is instead shown to be fierce and aggressive, with fangs, piercing yellow eyes, and wild hair
The other downside to this one is that unless you can remove it, you are obligated to pay the life and draw a card, so it is possible to lose to your own Phyrexian Arena
But seriously, even though the Future Sight border shenanigans clearly make the cards a bit more desirable, Mystery Booster 2 feels like a 'purer' product