Its not really built for it, but you can engage in it and it still has an interesting subgame for it. Sometimes the designers take existing mechanics like Unearth, which allows a player to replay a creature from their graveyard for one final attack, and tweak them to be better in multiplayer
Protection One of Magics strongest mechanics, protection X prevents a permanent or player from being targeted, enchanted, dealt damage by, or blocked by anything with characteristic X
Decks With This Card Recent public and tournament decks using Malefic Stardust Dragon
Then years later the deck got more of there cards from the Box Review: Explosion of Meteor Mini-Box
I shouldn't be wasting my time here
If the target creature is an illegal target by the time Path to Exile tries to resolve, the spell won't resolve