DOTA-C5-azide other NRX-252114 acts as molecular glue

NRX-252114 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

a Mal-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

08 Purity (HPLC) >= 95% Physical Appearance Orange Solid Optical Properties Abs/Em Maxima: 503/509nm Solubility DMSO

DOTA has been used in many different diagnostic and therapeutic applications

371 SMILES OCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DOTA-C5-azide other NRX-252114 acts as molecular glueDOTA bifucational chelator containing an azide group, an alkyl linker, and the macrocyclic chelator DOTA ( 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid). It can be used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents. Product Name DOTA C5 azide Synonyms CAS Number n a Related CAS Molecular Formula C21H38N8O7 Molecular Weight 514. 584 SMILES