DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB nitrogen 054 SMILES [2H]C([2H])([2H])OC1=CC=CC=C1Br Purity (HPLC)

054 SMILES [2H]C([2H])([2H])OC1=CC=CC=C1Br Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-acetamido-C4-azide Synonyms Thalidomide-4'-O-acetamido-C4-azide CAS Number 2098488-36-7 Related CAS Molecular Formula C19H20N6O6 Molecular Weight 428

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

1038/s41586-020-2760-4

specifically in the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction

DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB nitrogen 054 SMILES [2H]C([2H])([2H])OC1=CC=CC=C1Br Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing