Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)

821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG2 moiety to enhance aqueous solubility

Product Name Inavolisib Synonyms GDC-0077 CAS Number 2060571-02-8 Related CAS Molecular Formula C18H19F2N5O4 Molecular Weight 407

Product Name tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate Synonyms 1-Piperidineacetic acid

Product Name Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C83H136N12O23 Molecular Weight 1670

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,