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Id at least give Ego Drain a chance in testing before I give up on such a powerful tool

Tranquilize If youre playing a proliferate deck, Tranquilize seems like a great way to neutralize a potent attacker or blocker indefinitely

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Much of the time this means playing a couple Islands, but obviously it changes with whatever deck you're playing

In many color combinations and strategies, you wont even feel a restriction

Replicate currently only exists on instants and sorceries, but it can theoretically go on any spell