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This duo is likely going to take a lot from Ikoria proper, as ability counters will only help to bolster Nikara

Its totally up to you

It can send an equipped monster to the Graveyard to prevent its destruction and by sending a "Dupe Frog" or "Poison Draw Frog", it is possible to prevent a loss in card advantage, by drawing a card or search/retrieve a "Frog" monster

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This ranges from more meat on the battlefield to synergistic effects being pushed through the roof

On top of that, its very likely well be seeing more Secret Lair previews to accompany the Spongebob Squarepants drops in the next Superdrop