As I explained in my article "Metamorphosis 2.0," it wasn't until we took core sets away that we realized how much we'd relied on them for certain things: fitting in reprints that were world-specific, making cards to mechanically support themes in Standard or set up things that will eventually be relevant, helping players avoid fatigue as the core set is opt in, and most importantly, helping ramp new players into the game
It still has a place (mostly driven by nostalgia, probably) in dredge decks like Jarad, Golgari Lich Lord, and you absolutely have to run it on principle in Saffi Eriksdotter and Hans Eriksson decks
As you might have seen with Grenzo and Rusko, the best Alchemy commanders either create things for free or cast spells for free
In this case, the spell side provides an infinite-hand-size emblem while drawing you lots of cards, and the Sea Gate, Reborn side is an untapped mana source if needed early on
Marneus Calgar Stepping away from the conventional MTG planes and into Universes Beyond, Marneus Calgar is our one and only MTG Warhammer 40k commander worth talking about for cEDH
The last few cards I want to touch on are a nice tech card and the interaction